Archetypal otherness -- DNA vs. I Ching

Year: 
2007

Part B of Climbing Elven Stairways: DNA as a macroscopic metaphor of polarized psychodynamics. For access convenience this paper has also been split into two parts.



Introduction
Context of clashing cultures
Part A: Existential challenge of "The Other"
-- Contrast with framework of Spiral Dynamics
-- Possibility of an implicit pattern
-- Correspondences and complementarities: "moonshine connectivity"
-- A "hidden" stairway?
-- Spiral stairway -- threatening and/or broken?
-- Guarding the entrance: the "wisdom keepers"
-- Spiral stairwells and screw conveyors
-- Paradoxical existential dynamics of the spiral stairway
-- Fundamental knower-known relationship
Human relationships and "The Other"
Part B: Archetypal otherness: "DNA vs. I Ching"
-- Correspondences and complementarities: steps on the spiral way
-- Pattern replication
-- Process dynamics
-- "Broken symbols" exacerbating relationship failure?
-- Value polarities as archetypal bonds
-- Bonding: reification and petrification of significance
-- Relationship breakdown and civilizational collapse
References


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For access convenience this paper has been split into two parts. The unsplit version is also available


Correspondences and complementarities: steps on the spiral way

The earlier exploration (Theories of Correspondences -- and potential equivalences between them in correlative thinking, 2007) did not immediately highlight the nature of different correspondences. It is therefore appropriate to explore the extremely well-researched nature of the base pairs to which it is suggested here that the correspondences may be in some way analogous. The exploration is guided by the recognition that, whether in terms of microbiological processes or with respect to psychodynamic relationships, both are essential to life as it is experienced -- and that therefore, as argued above, some degree of similarity is to be tentatively hypothesized between them.

As noted in the helpful Wikipedia entry, in molecular biology a base pair is the connection via hydrogen bonds of two nucleotides on the opposite/complementary helical DNA (or RNA) strands. The base pairs are of two kinds in DNA, through which four nucleotides are connected as indicated in Table 1 (with the letters that conventionally denote them).

. Table 2: Bonding between nucleotide pairs
(linking the separate helical strands)
. purines
(double-ringed)
hydrogen bonding pyrimidines
(single-ringed)
Stable nucleotide
base pairs

adenine
(A)
 
AT pairing via
2 hydrogen bonds
thymine (T)
replaced by
uracil (U) in RNA

guanine
(G)
 
GC pairing via
3 hydrogen bonds

cytosine

(C)
 
Nonviable nucleotide
base pairs
adenine (A) mismatch: the pattern of hydrogen donors and acceptors do not correspond in an AC pair. cytosine (C)
guanine (G) mismatch: the pattern of hydrogen donors and acceptors do not correspond in a GT pair. thymine (T)
. purine-purine pairings are energetically unfavorable because the molecules are too close, leading to electrostatic repulsion. .
. pyrimidine-pyrimidine pairings are energetically unfavorable because the molecules are too far apart for hydrogen bonding to be established .

As a template, the two types of viable base pairing will be related below to the systematic metaphorical representation of psychodynamics developed by the I Ching coding system. The "steps" on the spiral stairway are the two-fold or three-fold bonds which in that system would be equivalent to the yin and yang line coding.

The number of base pairs is therefore equal to the number of nucleotides on a single strand. The human genome is estimated to be about 3 billion base pairs in length and to contain 20,000-25,000 distinct genes. Distinctiveness, and information carrying capacity, arise from the sequencing of the four different nucleotides along one strand (complemented by the sequencing of the corresponding nucleotides on the other). A gene may then be described as a union of genomic sequences of nucleotides encoding a coherent set of potentially overlapping functional products.

The genetic code is the set of rules by which information encoded in genetic material (DNA or RNA sequences) is translated into proteins (amino acid sequences) by living cells. Specifically, the code defines a mapping between tri-nucleotide sequences (called codons) and amino acids; every such triplet of nucleotides in a nucleic acid sequence then corresponds to a single amino acid as indicated in Table 3.

Table 3 : 20 different amino acids used by living cells to encode proteins
that are directly encoded for protein synthesis by the standard genetic code

(originally hypothesized because 3 is the smallest n such that 4n is at least 20)
[Source: table on Gene expression and biochemistry in Wikipedia. Notes omitted]
Amino Acid Abbreviations Codon(s) in RNA
[triplets of 3 nucleotides from Table 2,
using U instead of T ]
Occurrence
in proteins
(%)
Essential (X) /
Conditionally (C)
in humans
Alanine A Ala GCU, GCC, GCA, GCG 7.8 -
Cysteine C Cys UGU, UGC 1.9 C
Aspartic acid D Asp GAU, GAC 5.3 -
Glutamate E Glu GAA, GAG 6.3 -
Phenylalanine F Phe UUU, UUC 3.9 X
Glycine G Gly GGU, GGC, GGA, GGG 7.2 C
Histidine H His CAU, CAC 2.3 -
Isoleucine I Ile AUU, AUC, AUA 5.3 X
Lysine K Lys AAA, AAG 5.9 X
Leucine L Leu UUA, UUG, CUU, CUC, CUA, CUG 9.1 X
Methionine M Met AUG 2.3 X
Asparagine N Asn AAU, AAC 4.3 -
Proline P Pro CCU, CCC, CCA, CCG 5.2 -
Glutamine Q Gln CAA, CAG 4.2 C
Arginine R Arg CGU, CGC, CGA, CGG, AGA, AGG 5.1 C
Serine S Ser UCU, UCC, UCA, UCG, AGU, AGC 6.8 -
Threonine T Thr ACU, ACC, ACA, ACG 5.9 X
Selenocysteine U Sec UGA - -
Valine V Val GUU, GUC, GUA, GUG 6.6 X
Tryptophan W Trp UGG 1.4 X
Tyrosine Y Tyr UAU, UAC 3.2 C
Stop codon
- Term UAA, UAG, UGA - -

The above table may be represented in inverse form in Table 4. It is useful to recognize that each codon triplet in Table 3 or 4 is the representation on one strand of the ends of three base pairs. Implied by the nucleotides UAC, for example, is the existence of the corresponding nucleotides AUG with which they are bonded on the other strand -- thereby constituting three base pairs.

Table 4: 64 codons and the amino acid for which each codon codes (direction is 5' to 3')
[Inverse of Table 3. Source RNA Codon table in Wikipedia. Notes omitted ]
2nd base in codon triplet
U C A G
1st
base
(in
codon
triplet)
U

UUU (Phe/F) Phenylalanine
UUC (Phe/F) Phenylalanine
UUA (Leu/L) Leucine
UUG (Leu/L) Leucine

UCU (Ser/S) Serine
UCC (Ser/S) Serine
UCA (Ser/S) Serine
UCG (Ser/S) Serine

UAU (Tyr/Y) Tyrosine
UAC (Tyr/Y) Tyrosine
UAA Ochre (Stop)
UAG Amber (Stop)

UGU (Cys/C) Cysteine
UGC (Cys/C) Cysteine
UGA Opal (Stop)
UGG (Trp/W) Tryptophan

C

CUU (Leu/L) Leucine
CUC (Leu/L) Leucine
CUA (Leu/L) Leucine
CUG (Leu/L) Leucine

CCU (Pro/P) Proline
CCC (Pro/P) Proline
CCA (Pro/P) Proline
CCG (Pro/P) Proline

CAU (His/H) Histidine
CAC (His/H) Histidine
CAA (Gln/Q) Glutamine
CAG (Gln/Q) Glutamine

CGU (Arg/R) Arginine
CGC (Arg/R) Arginine
CGA (Arg/R) Arginine
CGG (Arg/R) Arginine

A

AUU (Ile/I) Isoleucine
AUC (Ile/I) Isoleucine
AUA (Ile/I) Isoleucine
AUG (Met/M) MethionineStart

ACU (Thr/T) Threonine
ACC (Thr/T) Threonine
ACA (Thr/T) Threonine
ACG (Thr/T) Threonine

AAU (Asn/N) Asparagine
AAC (Asn/N) Asparagine
AAA (Lys/K) Lysine
AAG (Lys/K) Lysine

AGU (Ser/S) Serine
AGC (Ser/S) Serine
AGA (Arg/R) Arginine
AGG (Arg/R) Arginine

G

GUU (Val/V) Valine
GUC (Val/V) Valine
GUA (Val/V) Valine
GUG (Val/V) Valine

GCU (Ala/A) Alanine
GCC (Ala/A) Alanine
GCA (Ala/A) Alanine
GCG (Ala/A) Alanine

GAU (Asp/D) Aspartic acid
GAC (Asp/D) Aspartic acid
GAA (Glu/E) Glutamic acid
GAG (Glu/E) Glutamic acid

GGU (Gly/G) Glycine
GGC (Gly/G) Glycine
GGA (Gly/G) Glycine
GGG (Gly/G) Glycine

This representation corresponds in a number of respects to that of the 64 hexagrams of the I Ching, as has been noted by several authors (Katya Walter, Tao of Chaos: merging East and West, 1996; Johnson F. Yan, DNA and the I Ching: the Tao of life, 1993; Martin Schonberger, The I Ching & the Genetic Code: the hidden key to life, 1979). Katya Walter has shown that the Fu Xi Earlier Heaven Ho Tu arrangement of the 64 hexagrams can represent the DNA genetic code:

Table 5: Relationship between I Ching hexagrams and amino acids
[Source: Katya Walter, Tao of Chaos: merging East and West, 1996]
I Ching hexagrams equivalence to DNA

The relationship of the codon triplets to the conventional hexagrams of the I Ching may be made in Table 6 by recognizing the implied corresponding half of the three base pairs represented in Table 4, and the 2 and 3-fold hydrogen bonding that distinguishes them. A single codon triplet (of three base pairs) in Table 4 is then equivalent as a code to a single I Ching hexagram. Note that conventionally the yin and yang elements are associated with the even and odd numbers, 2 and 3 -- matched here with the 2 and 3-fold base pair bonding.

Table 6: Possible equivalence of RNA/DNA base pairs with I Ching digram coding
Representation of base pairs constituting codons Conventional I Ching coding
Nucleotide bases
(explicit in Table 4)
hydrogen
bonds
Nucleotide bases
(implicit in Table 4: other strand)
Component of
hexagram
structure code number code nucleotide
structure
digram
name
double-ringed A 2 U (or T) single-
ringed
young_yin young yin
single-ringed U (or T) 2 A double-
ringed
old_yin old yin
double-ringed G 3 C single-
ringed
young_yang young yang
single-ringed C 3 G double-
ringed
old_yang old yang

[In this respect note discussion in Conditions of Objective, Subjective and Embodied Cognition: mnemonic systems for memetic coding of complexity, 2007].

In the light of the above correspondences, Chris Lofting (The Book of Structures: wholes, aspects, and the genetic code, 2005) treats the I Ching as a metaphor for the brain's way of dealing with objects (wholes, parts) and relationships (static, dynamic). H notes:

What this leads to is a model of thought based on strings of hexagrams, just as a coding sequence for a protein is based on strings of codons... Using the DNA/RNA pattern, there is a suggestion that we can produce strings that map to thoughts... Using the normal generation of a hexagram, we find that a hexagram links to a specific codon and so we use hexagrams to map strings of codons.



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